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KMID : 1102220230420010086
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Kidney Research and Clinical Practice
2023 Volume.42 No. 1 p.86 ~ p.97
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Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study
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Choi Hong-Sang
Kim Bong-Seong
Han Kyung-Do
Oh Tae-Ryom
Suh Sang-Heon
Kim Min-Ah
Kim Chang-Seong
Bae Eun-Hui
Ma Seong-Kwon
Kim Soo-Wan
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Abstract
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Background: Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However,the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease(DKD).
Methods: From the Korean National Health Insurance Service database, we selected 67,866 patients with DKD and body weightdata from two consecutive health examinations with a 2-year interval between 2009 and 2012. Weight change over 2 years was categorizedinto five groups: ≥?10%,
Results: During the 5.24-year follow-up, 17,023 patients with DKD developed depression. Weight change and the risk of depressionhad a U-shaped relationship: patients with ≥?10% weight change (hazard ratio [HR], 1.12) and those with ≥10% weight change (HR,1.11) showed higher HRs for depression than those with
Conclusion: Both weight loss and weight gain increased the risk of depression in patients with DKD.
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KEYWORD
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Depression, Diabetic nephropathies, Risk, Weight change
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